タンパク質 研究論文抄読 何をどれだけ？

Volume 19, Issue 3, 4 March 2014, Pages 407–417

Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

Highlights

• High protein intake is linked to increased cancer, diabetes, and overall mortality
• High IGF-1 levels increased the relationship between mortality and high protein
• Higher protein consumption may be protective for older adults
• Plant-derived proteins are associated with lower mortality than animal-derived proteins

Summary

Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we examined links between protein intake and mortality. Respondents aged 50–65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer death risk during the following 18 years. These associations were either abolished or attenuated if the proteins were plant derived. Conversely, high protein intake was associated with reduced cancer and overall mortality in respondents over 65, but a 5-fold increase in diabetes mortality across all ages. Mouse studies confirmed the effect of high protein intake and GHR-IGF-1 signaling on the incidence and progression of breast and melanoma tumors, but also the detrimental effects of a low protein diet in the very old. These results suggest that low protein intake during middle age followed by moderate to high protein consumption in old adults may optimize healthspan and longevity.

米国人を対象、タンパク質のみに着目、タンパク質由来のカロリー摂取で分類、
50歳以上の中年、65歳以上の高齢者、人の統計データとマウスの実験データ

この研究あなたはどう解釈されますか。

IGF-1はアンチエイジングには欠かせないものです。

毎日新しい医療情報、健康情報、食事方法など研究結果が発信紹介されています。
そしてインターネット上には人間が一生かかっても学ぶことができない
様々な情報、知識、ノウハウが蓄積されていきます。
昨日の常識は今日の非常識、今日の非常識が明日の常識。
振り回されることなく自分で決めて納得することです。

アンチエイジング、健康的なダイエットの基本は食事と適度な運動、睡眠です。
サプリだけで健康は維持できません。運動も、やりすぎはダメです。

ダイエット きっかけ 健康的 アンチエイジング